Predictive value of novel circulating biomarkers in Chagas disease: The Brazilian Chagas disease cohort
نویسندگان
چکیده
Abstract Introduction Chagas disease, caused by the protozoan Trypanosoma cruzi (T. cruzi), is leading causes of non-ischemic heart failure and premature cardiac deaths in Latin America. Identifying predictive biomarkers morbidity progression cardiomyopathy (CCC) important to deciphering novel pathways aid early identification patients at highest risk for future adverse cardiovascular (CV) outcomes. Objectives To determine association circulating with CCC disease survival. Methods Serum levels 184 unique cardiometabolic inflammation proteins were measured using proximity extension immunoassay age- sex- matched without history any other or infectious diseases as well diabetes mellitus, who identified selected referral outpatient center Disease a clinical hospital Brazil. Univariable linear regression standardized protein compared between CCC. All p-values adjusted multiple testing findings p value<0.0002 considered statistically significant. Proteins that reached significance level further mortalities We also performed network analysis STRING-DB on overexpressed its interaction. Results used data from 44 asymptomatic T. cruzi-positive (indeterminate). Among individuals CCC, 22 had fatal event during follow-up period 4.1 (SD ±1.4) years. In analyses, we 45 candidate associated chronic CC (all values <0.0002). these, only three (IL33, CD40, REG1A) significantly different died vs survived over 38 analysis. THBS4, marker remodeling, was CXCL11 seen co-expressed CXCL9 CXCL10, all are known activators CD4+ Th1 cells Conclusion inflammatory markers cardiomyopathy. Funding Acknowledgement Type funding sources: Public Institution(s). Main source(s): Leading House America Swiss State Secretariat Education, Research Innovation (SERI)
منابع مشابه
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Chagas' disease is a severe health problem in Latin America, causing approximately 50 000 deaths a year, with approximately 18 million infected people. About 25-30% of the patients infected with Trypanosoma cruzi develop the chronic form of the disease. The protective response against T. cruzi depends on both innate and acquired immunity involving macrophages, natural killer cells, T and B lymp...
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BACKGROUND AND PURPOSE Chagas disease (CD) is frequently associated with cardioembolic stroke in South America. Our objective was to identify the predictors of stroke in a region where CD is endemic. METHODS We screened 305 consecutive cardiopathy patients. Significant predictors of stroke in univariable analyses were included in a multivariable model. RESULTS Stroke was more frequent in CD...
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ژورنال
عنوان ژورنال: European Heart Journal
سال: 2022
ISSN: ['2634-3916']
DOI: https://doi.org/10.1093/eurheartj/ehac544.1795